Dasatinib therapy can result in significant pulmonary toxicity
نویسندگان
چکیده
منابع مشابه
Combination targeted pulmonary hypertension therapy in the resolution of Dasatinib-associated pulmonary arterial hypertension
Dasatinib is a small-molecule tyrosine kinase inhibitor used in the treatment of hematological malignancies. Pulmonary arterial hypertension (PAH) is a rare but known complication. The mainstay of treatment is cessation of Dasatinib, and while clinical improvement is rapid, complete hemodynamic resolution of pulmonary hypertension (PH) still remains exceedingly uncommon. We present a case of Da...
متن کاملPhiladelphia-negative clonal hematopoiesis is a significant feature of dasatinib therapy for chronic myeloid leukemia.
sia” in the paper by Ciurea et al1 should be replaced by “neoplastic accumulation of megakaryocytes.” The process is an accumulation of neoplastic, not hyperplastic, megakaryocytes as a result of an increased clonal production of megakaryocytes and a decrease in apoptotic signaling in the neoplastic megakaryocytes, as they have skillfully confirmed. The correct use of the term hyperplasia in no...
متن کاملPhiladelphia-negative clonal hematopoiesis is a significant feature of dasatinib therapy for chronic myeloid leukemia
sia” in the paper by Ciurea et al1 should be replaced by “neoplastic accumulation of megakaryocytes.” The process is an accumulation of neoplastic, not hyperplastic, megakaryocytes as a result of an increased clonal production of megakaryocytes and a decrease in apoptotic signaling in the neoplastic megakaryocytes, as they have skillfully confirmed. The correct use of the term hyperplasia in no...
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One hundred and ninety-five series of granulocyte transfusions in 144 patients were evaluated with respect to possible severe pulmonary toxicity from concomitant administration of granulocytes and amphotericin B. Dyspnea as a side effect of granulocyte transfusion was equally common among patients receiving amphotericin B and those in a matched control group not receiving amphotericin B. Granul...
متن کاملPulmonary arterial hypertension in patients treated by dasatinib.
BACKGROUND The French pulmonary hypertension (PH) registry allows the survey of epidemiological trends. Isolated cases of precapillary PH have been reported in patients who have chronic myelogenous leukemia treated with the tyrosine kinase inhibitor dasatinib. METHODS AND RESULTS This study was designed to describe incident cases of dasatinib-associated PH reported in the French PH registry. ...
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 2015
ISSN: 0361-8609
DOI: 10.1002/ajh.24194